Scientists have established a link between traumatic brain injury and death from brain cancer
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- Scientists have established a link between traumatic brain injury and death from brain cancer
People who have suffered a traumatic brain injury are 1.75 times more likely to die from brain cancer than the general population. This conclusion was reached by scientists who analyzed the data of more than 20 thousand patients. This was reported on June 10 in the journal Medical Xpress.
"Many people perceive traumatic brain injury solely as an acute event. But our data show that it can have long—term neurological consequences, including oncological ones, and it is important for both patients and doctors to be aware of this," said Daniel Daneshwar, senior author, director of the HealthSpan Lab and head of the Department of physical Medicine at Mass General Brigham.
The analysis covered patients from 20 rehabilitation centers in the United States, including Spaulding Rehabilitation Hospital, from 1987 to 2024. Deaths from brain cancer were determined by death certificates. For comparison, the expected indicators were used in a demographically comparable part of the general population, adjusted for age, gender, race, and year of follow-up.
The highest risk was found among victims of gunshot wounds to the head.: they died of brain cancer more than 14 times more often than normal. In patients with mild complicated traumatic brain injury, the risk was almost four times higher than the average. In moderate to severe injury, an increased risk was also observed, but it did not reach statistical significance, presumably due to the smaller size of this subsample.
The authors attribute the discovered pattern to the long-term effects of neuroinflammation triggered at the time of injury. According to their assessment, the results do not allow for an immediate revision of clinical guidelines, but they provide the basis for the development of cancer screening programs for survivors, primarily those who suffered a gunshot wound or a mild complicated injury.
Earlier on June 9, researchers from the Swiss Higher Technical School of Zurich discovered that the accumulation of an inactive form of the GRK2 protein may be a key factor in the development of Alzheimer's disease. The study showed that the GRK2 protein, which normally supports the functioning of nerve cells and the heart, begins to accumulate in the brains of people with dementia when it becomes inactive.
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