Experts have identified ethnic groups with the highest risk of diabetes

The analysis of more than 166 thousand genomes of Russian residents representing different ethnic groups revealed differences in the risks of developing type 2 diabetes. According to Genotek specialists, an increased predisposition is more common among Azerbaijanis, while this indicator is minimal among Yakuts. I got acquainted with the results of the study on December 12 "Газета.Ru ".

"Genetics plays a key role in the development of type 2 diabetes. This is not a single gene disease — it is affected by many small genetic factors that add up together. By understanding this polygenic nature of diabetes, we can more accurately assess the risks and select more effective and personal ways of prevention and treatment," explained Alexander Rakitko, head of the study and Director of Science at Genotek.

According to Genotek, experts have studied the prevalence of the TCF7L2 gene variant (rs7903146), recognized as one of the strongest genetic risk factors for the disease. The presence of two T alleles doubles the likelihood of developing type 2 diabetes compared to carriers of the CC variant.

According to the results of the analysis, the most common risky set of alleles is found in Azerbaijanis (16.03%), followed by Armenians (15.16%) and Chechens (10.38%). The minimum frequency was found in Yakuts (0.14%) and Bashkirs (1.1%). No risk variants were found among the Koreans studied.

"Genetic predisposition is an important part of the clinical picture, it helps to assess individual risks of developing type 2 diabetes. Even in the presence of a risky variant of the gene, lifestyle, dietary patterns, and physical activity remain key factors in prevention. The data obtained allows us to more accurately build predictive recommendations for different population groups and each individual patient," said Marina Stepkovskaya, Genotek's general practitioner, PhD.

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