A database of dangerous side effects of advanced cancer drugs has been created in the Russian Federation

Scientists at the Center for Mathematical Modeling in Drug Development at Sechenov University have developed and registered the first database that contains information on the side effects of checkpoint inhibitors and their combinations in immuno-oncological drugs. These drugs have changed the approach to cancer treatment and opened a new era in cancer therapy, the developers said.

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However, despite the significant advances in the treatment of the disease achieved with their help, they also have undesirable effects that need to be taken into account. The database will be used by developers of new drugs to select the optimal dosage of the drug when planning clinical trials.

"We started collecting the database back in 2018, the year we received the Nobel Prize. At that time, all major checkpoint inhibitors were already available on the market and a pool of clinical data on the safety of using different types of therapies had accumulated," Kirill Peskov, head of the Center for Mathematical Modeling in Drug Development at Sechenov University, told Izvestia.

The database is constantly updated. The developers include information on the results of clinical trials of innovative checkpoint inhibitors and biosimilars that are appearing in Russia and around the world. The technology will become part of a digital platform for mathematical modeling of oncological diseases for the development of new drugs being developed at Sechenov University.

Read more in the exclusive Izvestia article:

State of effects: a database of dangerous side effects of advanced cancer drugs has been created in the Russian Federation