Scientists have found a way to improve the treatment of aggressive brain tumors

Scientists from the Institute of Biology and Biomedicine of the National Research Nizhny Novgorod State University (NNSU) named after N.I. Lobachevsky and Ghent University (Belgium) proposed to influence several ways of cell death of the most aggressive brain tumor, glioblastoma, thus reducing the likelihood of their resistance to temozolomide.

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Launching several deadly cellular cascades will also potentially allow fighting functionally different cells inside the tumor. Researchers have already shown the possibility of this approach in a number of studies using animals as experimental models.

According to the proposed approach, in parallel with the launch of the classical mechanism of action of temozolomide, an alternative pathway of cell death is activated, which has immunogenic properties, helping the immune system to become a participant in the fight against neoplasm. You can start it with the help of additional medications or some physical effects, such as ultrasound.

"Temozolomide is an attractive chemotherapeutic agent for the proposed combination therapy, which will improve the effectiveness and quality of treatment for patients with glioblastomas," Tatiana Mishchenko, project manager, Associate professor of the Department of Neurotechnology at the Institute of Biology and Biomedicine of the National Research University, told Izvestia.

Scientists have proposed using a combined approach using nanocarriers that allow targeted delivery of temozolomide and other substances necessary to trigger immunogenic cell death to the tumor. Targeted delivery will reduce possible side effects on healthy human cells.

Read more in the exclusive Izvestia article on Tuesday, April 1, at 10:00 a.m.:

Cellular calculation: a way has been found to improve the treatment of aggressive brain tumors