New antibiotic will kill invincible Staphylococcus aureus

MIPT researchers have synthesized a molecule capable of fighting antibiotic-resistant Staphylococcus aureus. This dangerous infection often causes serious illnesses. Some of its variants have developed resistance to the usual antimicrobial drugs, so their suppression has become a serious problem. Studies have shown that an antibiotic created by scientists can successfully fight infection and therefore can be considered as the basis for a new drug.

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How scientists synthesized drugs against resistant microorganisms with additional effects

"We studied a group of triazenoindole substances and selected the most effective molecule from them. These compounds are used as prototypes of drugs against tuberculosis, its causative agent is mycobacteria, therefore it is a natural candidate for use as an antibiotic against staphylococcus. They are also known to have an antifungal effect. Experiments have confirmed this. We assume that the molecule has a double effect on the bacterium. The synthesis of cell membrane components is disrupted, as well as the work of the DNA gyrase enzyme, but we intend to study this mechanism in more detail in future studies," Denis Kuzmin, one of the authors of the work, director of the Phystech School of Biological and Medical Physics at MIPT, told Izvestia.

According to the expert, the stage of preclinical research, including animal experiments, will take about a year. After that, the scientists intend to start testing with humans.

Read more in the exclusive Izvestia article:

Without a single strain: new antibiotic will kill invincible Staphylococcus aureus