Pseudomonas aeruginosa toxins will specifically destroy diseased cells

During the research, MIPT specialists found out that the simultaneous use of two types of molecules containing Pseudomonas aeruginosa toxins is able to target the cells of tumors of the breast, stomach and some other organs. They can be used as a means of combating those cancers whose markers are considered to be changes in the expression of HER2 and EpCAM proteins.

Cancer will be defeated: new method defeats resistance of aggressive brain tumor

How scientists' proposed approach would make a dangerous neoplasm susceptible to chemotherapy

The compounds found by scientists affect diseased cells and do not damage healthy ones. Thanks to this, it will be possible to develop new drugs for malignant neoplasms and strategies for combined targeted therapy based on them.

"Most studies now use similar full-size antibodies to recognize and target cancer cells. They work well, but they are very difficult to produce. We took a simplified version of them, the smaller molecules DARP_9.29-LoPE and DARP_EC1-LoPE. And it turned out that they work just as well and are no less specific against cancer cells," explained Anastasia Obozina, a junior researcher at MIPT.

According to the expert, combined cancer control strategies are being actively developed all over the world. The proposed approach can be very effective, but further research is needed for more accurate estimates.

Read more in the exclusive Izvestia article:

A cancerous case: Pseudomonas aeruginosa toxins will specifically destroy diseased cells