Database of immune cell aging will enable the creation of HIV drugs

Scientists from the Center for Mathematical Modeling in Drug Development at Sechenov University, together with researchers from the Institute of Computational Mathematics of the Russian Academy of Sciences and foreign colleagues, have analyzed more than 120 clinical trials aimed at studying the homeostasis of T-lymphocytes in people of different ages and quantitatively characterized the dynamics of immune cell aging.

"Each clinical trial we analyzed has a limited data set in terms of both number of participants and their age. By taking a systematic approach to collecting and analyzing all available information, we were able to capture not only a huge number of measurements, but also an unprecedented range in age, from newborns to long-lived individuals. The oldest person from our database was 111 years old", said the author of the work, junior researcher of the center Victoria Kulesh.

According to her, the results of the study are planned to be used to develop a system-pharmacological platform for mathematical modeling of infectious diseases, in particular HIV.

Read more in Izvestia's exclusive piece:

Lymphocyte attention: the base of immune aging will help to create drugs against HIV